以前得过季节性流感？恭喜你，你对当前流行的H1N1流感已经有了一些抵抗力。研究人员在最新一期的《美国科学院院报》上报告说，H1N1流感病毒表面与最近的季节性流感病毒约有17%的相似标记，能够被人体免疫系统识别；另一种称为T细胞的免疫细胞，则能识别H1N1 病毒中约69%的标记。@科学公社

消息来源：Eurekalert！中文版

Pre-existing immunity against H1N1 flu

公开发布日期: 2009年11月17日

Previous flu infections are likely to provide some immunity against the ongoing H1N1 influenza virus pandemic. These findings may help quell concerns that the H1N1 virus is so different from previous seasonal human influenza strains that there was no existing immunity in the population. Bjoern Peters and colleagues used the Immune Epitope Database to compare which molecular markers of the H1N1 influenza virus might be similar to molecular markers on the surface of previous seasonal influenza strains. The authors discovered that the human body's defense system recognized approximately 17 percent of the markers that are shared with recent seasonal influenza strains on the surface of the H1N1 virus. Other immune cells called T cells, which can also detect virus-infected cells, recognized 69 percent of the markers in the H1N1 virus. The high percentages of recognition suggest that pre-existing immunity in humans and animals may provide a barrier against pandemic strains and help to blunt the impact of widespread infection. A vaccine, however, is still needed to contain the unique markers carried on the surface of the H1N1 influenza virus, according to the authors.

Article #09-11580: "Pre-existing immunity against swine-origin H1N1 influenza viruses in the general human population," by Jason A. Greenbaum, Maya F. Kotturi, Yohan Kim, Carla Oseroff, Kerrie Vaughan, Nima Salimi, Randi Vita, Julia Ponomarenko, Richard H. Scheuermann, Alessandro Sette, and Bjoern Peters